Because the side chains of the amino acids are important in determining many properties of the polypeptide, it is useful to group amino acids according to classifications that are relevant to polypeptide properties.
Amino acids that have acidic or basic groups in their side-chains are classed as
electrically charged because at pH 7
the acid -CO
2H donates H
+ to water and exists as -CO
2–
basic nitrogen accepts H
+ from water to form -NH
+-

All of the the bonds in amino acids are covalent with electron pairs being shared. Polar bonds have unequal sharing, and one of the bonded atoms is slightly negative and the other is slightly positive.
N-H, C=O, O-H and S-H bonds are polar. Amino acids that are not electrically charged but have side-chains with polar bonds are classed as
polar.
Other amino acids are classed as
nonpolar.
Nonpolar amino acids often have only C-H bonds in their side chains.